Endocrine Abstracts

Background: Insulin resistance (IR) is the common denominator of three multigenic disorders: type 2 diabetes mellitus, obesity, and PCOS. IR can result from genetic abnormalities involving proteins of the insulin signalling pathway, including PC-1 and IRS-1. The IRS-1 G972R variant had the highest world frequency and correlated with IR in PCOS Sicilian women (Horm Metab Res, 2010).Objective and methods: To determine: i) the rates of the G972R IRS-...